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These metabolites, particularly bacterial metabolites, play an important role in microbiotahost interactions and influence the immune system and the BM microenvironment

doi: 10.1073/pnas.2109721118 88 YagasakiHSanoFNarusawaHWatanabeDKagaYKobayashiKet al

Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015

Other useful proteins are substantially identical (e.g., at least about 40%, preferably 50%, 60%, 70%, 75%, 80%, 83%, 85%, 88%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99%) to one of these sequences and retain the protein functional activity of the corresponding naturally occurring protein, but differ in amino acid sequence due to natural allelic variation or mutagenesis